In silico designing of DASM with Pyrazofurin, a possible drug candidate for Anthrax
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Abstract
Bacillus anthracis is a notorious occupational zoonotic agent causing anthrax to veterinarians.
In this study, for the purpose of lead development, Dehydro Andrographolide Succinic acid Monoester (DASM) inhibitor of Furin was selected as a template.Anthrax infection is highly lethal in its most virulent form and produces a combination of three endotoxins namely Protective antigen, Lethal factor and Edema factor.
Furin is involved in other diseases, DASM was modified by adding anti-cancer, anti-inflammatory, anti-tuberculosis and anti-viral groups.
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