In-silico discovery of potential anti-malarial drugs targeting pfATP6 using Artemisinin as a model
Main Article Content
Abstract
Malaria is one among the major reasons responsible for deaths worldwide than any other parasitic disease.
Due to the emergence of strains that are resistant to the current chemotherapeutic antimalarial arsenal, the search for new antimalarial drugs remains urgent though hampered by a lack of knowledge regarding the molecular mechanisms of artemisinin resistance.
In this study, pfATP6 is used as a target to come up with different compounds that have high binding affinity to it. Artemesinin constitutes the frontline treatment to aid rapid clearance of parasitaemia and quick resolution of malarial symptoms. Artemesinin, which is the current anti-malarial, has some drawbacks like low bioavailability which makes it even more necessary to develop more effective anti-malarial drugs.
Downloads
Article Details

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
License Statement
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Authors who publish with International Journal of Fundamental and Applied Sciences (IJFAS) retain copyright of their articles and grant the journal the right of first publication.
This license allows others to share, use, and build upon the work—commercially or non-commercially—as long as appropriate credit is given to the original authors and source, and any changes are indicated.
The journal encourages open access and supports the free exchange of knowledge while ensuring proper attribution of original work.